The International Regulome Consortium

The Steering Committee

• Michael Rudnicki (mrudnicki@ohri.ca) is a Senior Scientist at the Ottawa Hospital Research Institute, and a Professor of Medicine at uOttawa. He is the Director of the Sprott Centre for Stem Cell Research and is Scientific Director of the Stem Cell Network. He holds the Canada Research Chair in Molecular Genetics, is an International Scholar of the Howard Hughes Medical Institute, and a Fellow of the Royal Society of Canada. Rudnicki's lab has made many seminal discoveries concerning the function of regulatory genes that regulate myogenic stem cell proliferation and differentiation. As Scientific Director of the IRC, he chairs the Steering Committee and reports to the IRC Board of Directors. He will be responsible for all aspects of the Canadian project.

• Irwin Davidson (irwin@titus.u-strasbg.fr) is the Director of Research at the Centre Nationale de la Recherche Scientifique in France and Staff Scientist in the Laboratoire de Génétique Moléculaire des Eucaryotes/IGBMC. He was the initiator of the French research network for the IRC. His laboratory was the first to investigate the function of TAFs in signaling and developmental processes in mammalian systems in vivo. Davidson leads the French effort including supervision of gene targeting and mouse production in collaboration with researchers Pierre Ferrier, Jacques Samurut and others.

• Jack Greenblatt (jack.greenblatt@utoronto.ca) is an Ann and Max Tannenbaum Professor of Molecular Medicine at the University of Toronto. He is a Fellow of the American Academy of Microbiology and a Fellow of the Royal Society of Canada. Greenblatt has conducted pioneering research on protein-protein interactions and on fundamental mechanisms that regulate gene expression in bacteria, viruses, yeast, and human cells. He performs high-throughput analysis of TF complexes by mass spectrometry.

• Frank Grosveld (f.grosveld@erasmusmc.nl) is Professor of Cell Biology and Genetics and Director of Erasmus Medical Center in the Netherlands. His work has primarily focused on the regulation of transcription of the human globin genes. He also has an active interest in the development of the haematopoietic and nervous systems. He was recently the leader of EuTRACC, and is the direct supervisor of the Genomics, Proteomics and Bioinformatics groups at Erasmus University.

• Bing Lim (limb1@gis.a-star.edu.sg) is the Associate Director at the Genome Institute of Singapore. In addition, he is the Senior Group Leader for the Stem Cell and Developmental Biology Group, co-coordinating the Transcriptome mapping project. He is also an Associate Professor of Medicine, Harvard Medical School and Associate Physician, Beth Israel Hospital. His primary interest is in embryonic stem cells - identifying and understanding the role of genes important both for maintaining the pluripotent state and differentiation as well as investigating the role of micro-RNAs in the differentiation process. Lim leads the Singapore team.

• Frances Stewart (stewart@mpi-cbg.de) leads a German stem cell consortium involving ten principal investigators. He is a Senior Scientist at the Dresden University of Technology. DiGToP focuses on how mutations cause disease using proteomic mapping.

• Jyoti Choudhary (jc@sanger.ac.uk) is Head of Mass Spectrometry at the Wellcome Trust Sanger Institute, Hinxton, Cambridge UK. She received her Ph.D. from the Imperial College, London, in the Biological Mass Spectrometry group of Prof. Howard Morris were she worked on developing biochemical and analytical methods for elucidating primary structure of proteins. She is a founding member of Cellzome AG, in the UK. She led the analytical group and contributed in establishing the TAP-MS platform for characterizing mammalian protein complexes. Dr. Choudhary’s research group at the Sanger Institute, Cambridge UK, is focused on developing and applying proteomic mass spectrometry methods for studying protein interactions and cell signalling.

• Uma Lakshmipathy (uma.lakshmipathy@lifetech.com) is a Principal Scientist at Life Technologies in Carlsbad, California and involved in the development of novel tools and technology platforms for stem cells. Her current research interests are regulation of stem cell maintenance, development of technologies for identification, characterization and differentiation of stem cells.