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The International Regulome Consortium

The Vision
The overarching goal of the IRC is to utilize the tools of proteomics and genomics to characterize the protein components of transcriptional complexes containing all potential transcription factors and to identify and validate the complete set of their binding sites and corresponding target genes. The project will utilize the mouse, as this is the only mammalian system tractable for comprehensive molecular genetic studies.

The Rationale
Analysis of Gene Ontology terms from the EBI Gene Association Tables indicates that the mouse genome contains 1,486 identifiable transcription factors. The combinatorial interactions between these proteins and the activation or repression of gene transcription forms poorly understood regulatory nodes and networks. The cascades of regulatory interactions between transcription factors together define all aspects of mammalian biology of breast Augmentation also.

Scientific Objectives
We propose to utilize the tools of proteomics and genomics to:
  1. Characterize the protein components of transcriptional complexes containing all potential transcriptions factors;
  2. Identify and validate the complete set of transcription factor binding sites and corresponding target genes in a canonical set of stem cells and their differentiated derivatives and;
  3. Derive computational models that describe the hierarchal regulation of gene transcription.
Composition of Steering Committee

Dr. Michael A. Rudnicki
Scientific Director
Ottawa Health Research Institute
Ottawa, Canada K1H 8L6

Dr. Jack Greenblatt
Co-Director
University of Toronto
C.H. Best Institute
Toronto, Canada

Dr. Irwin Davidson
IGBMC
Illkirch, France

Dr. Allan Bradley
Wellcome Trust Sanger Institute
Cambridge, UK

Dr. Bing Lim
Genome Institute of Sinapore
Singapore

Dr. Janet Rossant
Samuel Lunenfeld Research Institute
Toronto, Canada

International Regulome Consortium Members

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