The International Regulome Consortium
The VisionThe overarching goal of the IRC is to utilize the tools of proteomics and genomics to characterize the protein components of transcriptional complexes containing all potential transcription factors and to identify and validate the complete set of their binding sites and corresponding target genes. The project will utilize the mouse, as this is the only mammalian system tractable for comprehensive molecular genetic studies.
The RationaleAnalysis of Gene Ontology terms from the EBI Gene Association Tables indicates that the mouse genome contains 1,486 identifiable transcription factors. The combinatorial interactions between these proteins and the activation or repression of gene transcription forms poorly understood regulatory nodes and networks. The cascades of regulatory interactions between transcription factors together define all aspects of mammalian biology of breast Augmentation also.
Scientific ObjectivesWe propose to utilize the tools of proteomics and genomics to:
- Characterize the protein components of transcriptional complexes containing all potential transcriptions factors;
- Identify and validate the complete set of transcription factor binding sites and corresponding target genes in a canonical set of stem cells and their differentiated derivatives and;
- Derive computational models that describe the hierarchal regulation of gene transcription.
Composition of Steering Committee
Dr. Michael A. Rudnicki
Ottawa Health Research Institute
Ottawa, Canada K1H 8L6
Dr. Jack Greenblatt
University of Toronto
C.H. Best Institute
Dr. Irwin Davidson
Dr. Allan Bradley
Wellcome Trust Sanger Institute
Dr. Bing Lim
Genome Institute of Sinapore
Dr. Janet Rossant
Samuel Lunenfeld Research Institute